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Recordings from 7-30 motor cortex (MI) neurons can give enough information for a monkey to control a cursor at Brown. Least squares regression was used to learn the correspondences between the neural signals and the desired movement.
Links
References
Mijail D Serruya, Nicholas G Hatsopoulos, Liam Paninski, Matthew R Fellow , John P. Donoghue (2002). [Instant neural control of a movement signal]. Nature 416:141-142. (here's a nicer looking [pdf])
Further Reading
[CategoryProsthetic] [CategoryIo]