Large Database of Spontaneous and Evoked Activity Patterns in Developing Networks
Substrate-Integrated Micro-Electrode Arrays, Reutlingen, Germany, July 2006
We have made available on the web a comprehensive (>40GB) set of multi-unit spike data on cultures of dissociated embryonic rat cortex. We studied 58 cultures of different densities (3,000 to 50,000 neurons on areas of 30 to 75 mm2) growing on multi-electrode arrays (Multichannel Systems) during the first five weeks of their development [1]. Half-hour recordings of spontaneous activity were made almost daily, as well as network responses evoked by stimulating each electrode sequentially. The dataset also includes 36 long (overnight) recordings.
[1] Wagenaar, D. A., Pine, J., & Potter, S. M. (2006) An extremely rich repertoire of bursting patterns during the development of cortical cultures. BMC Neuroscience 7, 11.