Immo E. Scheffler

Recent Publications



Scheffler, I.E. 2008. MITOCHONDRIA. 2 nd edition, J. Wiley and Sons, New York . 462 pages.

Sonoda, J.,Laganiere, J., Mehl, I.R., Bari sh, G.D., Chong, L.W., Li, X., Scheffler, I.E ., Mock, D.C. Bataille, A.R., Robert, F., Lee, C.H. Giguere, V., Evans, R.M. (2007) Nuclear receptor ERR alpha and coactivator PGC-1 beta are effectors of IFN-gamma-induced host defence. Genes Dev. 21:1909-1920.

Yadava, N., Potluri, P., and I.E. Scheffler (2007) Investigations of the potential effects of phosphorylation of the MWFE and ESSS subunits on complex I activity and assembly. The Int. J. of Biochem. and Cell Biol. In press.

Broderick, K.E., Potluri, P., Zhuang, S., Scheffler, I.E., Sharma, V.S., Pilz, R.B., and Boss, G.R. (2006) Cyanide detoxification by the cobalamin precursor cobinamide. Exp. Biol. and Medicine 231: 641-649.

I. E. Scheffler , N. Yadava, and P. Potluri. (2004) Molecular Genetics of Complex I-Deficient Chinese Hamster Cell Lines. Biochim.Biophys. Acta. 1659: 160 - 171.

Ricci, J.-E., Munoz-Pinedo, C., Fitzgerald, P., Bailly-Maitre, B., Perkins, G.A., Yadava, N., Scheffler, I.E ., Ellisman, M.H., and Green, D.R. (2004) Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit (NDUSF1) of complex I of the electron transport chain. CELL 117: 1-20

Scheffler, Immo E. (2004) The Human OXPHOS system: Structure, Function, Physiology. Chapter 1 in Oxidative Phosphorylation in Health and Disease. J.A.M. Smeitink, R.C.A. Sengers, J.M. F. Trijbels, editors. Landes Bioscience and Kluwer Academic/Plenum Publishers.

Nagendra Yadava, Toby Houchens, Prasanth Potluri, and Immo E. Scheffler (2004). Development and Characterization of a Conditional Mitochondrial Complex I Assembly System. J. Biol. Chem. 279: 12406 - 12413.

Nagendra Yadava, Immo E. Scheffler (2004). Import and orientation of the MWFE protein in mitochondrial NADH-ubiquinone oxidoreductase. Mitochondrion 4: 1-12 .

Prasanth Potluri, Nagendra Yadava and Immo E. Scheffler. (2004). The role of the ESSS protein in the assembly of a functional and stable mammalian mitochondrial complex I (NADH-ubiquinone oxidoreductase). Eur. J. Biochem. 271: 3264 - 3273.

Scheffler, I.E. (2003) Mitochondrial dysfunction in genetic diseases. Chapt. 11 in Redox-Genome Interactions in Health and Disease. (Fuchs, ed). Marcel Dekker, Inc. New York, N.Y. .

Albayrak, T., Schoenfeld, N., Brazilius, E., Mund, T., Scherhammer, V., Bauer, M.K.A., Scheffler, I.E., and S. Grimm (2003) Complex II of the respiratory chain is a sensor for drug-induced apoptosis: identification by a screen for proapototic genes. Molec. Biol. Cell. 14: 3082-3096

Yadava, N., Potluri, P., Smith, E.N., Bisevac, A., and Scheffler, I.E. (2002) Species-specific and mutant MWFE proteins: their effect on the assembly of a functional mammalian mitochondrial complex I. J. Biol. Chem. 277: 21221-21230

de la Cruz, B.J., Prieto, S., and Scheffler, I.E. 2002. The role of the 5' untranslated region (UTR) in glucose-dependent decay and selective translation of yeast mRNAs. YEAST. 19: 887-902

Yadava, N., Potluri, P., Smith, E.N., Bisevac, A., and Scheffler, I.E. 2002. Species-specific and mutant MWFE proteins: their effect on the assembly of a functional mammalian mitochondrial complex I. J. Biol. Chem. 277: 21221-21230

Scheffler, I.E., Yadava, N. 2001. Molecular genetics of the mammalian NADH-ubiquinone oxidoreductase. J. Bioenerg. Biomembr. 33: 243 - 250

Scheffler, I.E. 2001. Mitochondria make a comeback. Adv. Drug Delivery Rev. 49: 3 - 26

Scheffler, I.E. 1999. MITOCHONDRIA.  J. Wiley and Sons, New York. 364 pages. June 1999

Scheffler, I.E., 2000. A century of mitochondrial research: achievements and perspectives. Mitochondrion 1: 3 - 31.

Prieto, S., B. J. de la Cruz, and Scheffler, I.E. 2000. Glucose-regulated turnover of mRNA and the influence of poly(A) tail length on half life. J. Biol. Chem. 275: 14155-14166.

Au, H.C., Seo, B.B., Yagi, A., Yagi, T., and I.E. Scheffler. 1999. The NDUFA1 gene product (MWFE protein)  is essential for activity of complex I in mammalian mitochondria. Proc. Natl. Acad. Sci. USA, 96: 4354-4359.

Au, H.C., Mascarello, J.T., and I.E. Scheffler. 1999. Targeted integration of a dominant neoR marker into a 2 - 3 Mb human minichromosome and transfer between cells. Cytogenet. and Cell Genet. 86:194-203.

Scheffler, I.E., De la Cruz, B.J., Prieto, S. 1998. Control of mRNA turnover as a mechanism of glucose repression in Saccharomyces cerevisiae. Invited Review. The International J. of Biochem. and Cell Biol. 30: 1175-1193.

Seo, B.B., Kitajima-Ihara, T., Chan, E.K.L., Scheffler, I.E., Matsuno-Yagi, A., and T. Yagi. 1998. Molecular remedy of complex I defects: Rotenone-insensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae mitochondria restores the NADH oxidase activity of complex I-deficient mammalian cells. Proc. Natl. Acad. Sci. USA., 95: 9167 - 9171.

Elbehti-Green, A., Au, H.C., Mascarello, J.T., Ream-Robinson, D., and I.E. Scheffler. 1998. Characterization of the human SDHC gene encoding one of the integral membrane proteins of succinate-quinone oxidoreductase in mitochondria. Gene 213: 133 - 140

Scheffler, I.E. 1998. Molecular genetics of succinate:quinone oxidoreductase in eukaryotes. Progress in Nucl. Acids Res. and Mol. Biol. 60: 267-315.

Au, H.C. and I.E. Scheffler. 1998. Analysis of the promoter of the human succinate dehydrogenase iron-protein gene: both nuclear regulatory factors NRF-1 and NRF-2 are required. Eur.J. Biochem. 251: 164-174.

Lorenzini, E.C., and I.E. Scheffler. 1997. Cooperation of the 5'and 3'-untranslated regions of ornithine decarboxylase mRNA and inhibitory role of its 3'-untranslated region in regulating the translational efficiency of hybrid RNAs via cellular factors. Biochem J. 326: 361-367

Au, H. C. and I. E. Scheffler. 1997. A respiration-deficient Chinese hamster cell line with a defect in mitochondrial protein synthesis:  Effect on nuclear and mitochondrial transcripts. Somat. Cell Molec. Genet. 23:  27 - 35.

A 2-3 Mb human minichromosome with the centromere from chromosome 1


Human minichromosome transferred from a hamster hybrid cell line to mouse LMTK- cells. FISH analysis before and after flow sorting. (see Au, Mascarello and Scheffler for details. Flow sorting by CHROMOS, Inc. Vancouver)

from the review in The International J. of Biochem. and Cell Biol. 30: 1175-1193.
see also: Prieto et al, 2000. J. Biol. Chem.

Links to Class Web Pages

Metabolic Biochemistry BIBC102

Human Molecular Genetics (BIMM 110)

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