Table S1. Eukaryotic Members of the Bestrophin Family1

 

Abbreviation

Organism

Residues

(# aas)

# of TMS (WHAT)

# of TMS (HMMTOP)

# of TMS (TMHMM)

# of TMS (Phobius)

Average # of TMSs2

gi Number3

Animal

 

 

 

 

 

 

 

 

Aga1

Anopheles gambiae

683

4

5

3

4

4.0

31240707

Aga2

Anopheles gambiae

446

4

4

3

5

4.0

31210675

Cbr1

Caenorhabditis briggsae

450

4

4

3

4

3.8

39587715

Cbr2

Caenorhabditis briggsae

566

6

7

5

6

6.0

39579041

Cbr3

Caenorhabditis briggsae

455

4

6

4

5

4.8

39590780

Cbr4

Caenorhabditis briggsae

499

4

4

2

6

4.0

39585641

Cbr5

Caenorhabditis briggsae

533

2

2

2

2

2.0

39587888

Cbr6

Caenorhabditis briggsae

515

4

4

4

4

4.0

39594972

Cbr7

Caenorhabditis briggsae

488

4

4

2

5

3.8

39583023

Cbr8

Caenorhabditis briggsae

434

4

4

2

4

3.5

39593542

Cbr9

Caenorhabditis briggsae

436

5

6

4

4

4.8

39583576

Cbr10

Caenorhabditis briggsae

418

4

4

1

6

3.8

39588164

Cbr11

Caenorhabditis briggsae

486

5

5

2

5

4.3

39586146

Cbr12
Caenorhabditis briggsae

612

4

5

4

4

4.3

39586926

Cbr13

Caenorhabditis briggsae

546

4

4

3

5

4.0

39586925

Cbr14

Caenorhabditis briggsae

405

4

4

3

4

3.8

39597589

Cbr15

Caenorhabditis briggsae

400

5

4

4

4

4.3

39593373

Cbr16

Caenorhabditis briggsae

413

4

4

4

4

4.0

39585767

Cbr17

Caenorhabditis briggsae

399

4

4

4

4

4.0

39584139

Cbr18

Caenorhabditis briggsae

629

4

5

4

5

4.5

39589646

Cbr19

Caenorhabditis briggsae

341

4

4

3

5

4.0

39582077

Cbr20

Caenorhabditis briggsae

353

5

4

3

3

3.8

39585918

Cbr21

Caenorhabditis briggsae

461

5

4

4

4

4.3

39590605

Cel1

Caenorhabditis elegans

450

4

4

4

5

4.3

17538330

Cel2

Caenorhabditis elegans

584

6

5

4

6

5.3

17538878

Cel3

Caenorhabditis elegans

459

5

4

4

5

4.5

17552094

Cel4

Caenorhabditis elegans

480

4

4

2

6

4.0

32566098

Cel5

Caenorhabditis elegans

1447

4

8

6

8

6.5

17542474

Cel6

Caenorhabditis elegans

525

4

4

4

4

4.0

32566051

Cel7

Caenorhabditis elegans

512

5

4

4

6

4.8

17505941

Cel8

Caenorhabditis elegans

309

2

1

0

0

0.8

33285175

Cel9

Caenorhabditis elegans

551

5

5

2

6

4.5

17543096

Cel10

Caenorhabditis elegans

551

5

8

5

7

6.3

17544172

Cel11

Caenorhabditis elegans

613

6

5

3

7

5.3

7507956

Cel12

Caenorhabditis elegans

612

4

5

4

4

4.3

17531405

Cel13

Caenorhabditis elegans

557

4

4

3

5

4.0

17531409

Cel14

Caenorhabditis elegans

405

4

4

3

4

3.8

2497031

Cel15

Caenorhabditis elegans

400

4

6

4

4

4.5

17560482

Cel16

Caenorhabditis elegans

413

4

4

4

5

4.3

17540114

Cel17

Caenorhabditis elegans

420

5

3

4

4

4.0

17539168

Cel18

Caenorhabditis elegans

632

4

5

4

5

4.5

17557055

Cel19

Caenorhabditis elegans

884

8

12

9

10

9.8

17538596

Cel20

Caenorhabditis elegans

411

4

3

3

4

3.5

17511109

Cel21

Caenorhabditis elegans

400

5

4

1

4

3.5

17506139

Cel22

Caenorhabditis elegans

530

4

5

3

5

4.3

7511358

Cel23

Caenorhabditis elegans

434

4

4

3

5

4.0

17559672

Cel24

Caenorhabditis elegans

444

7

7

6

6

6.5

17506141

Cel25

Caenorhabditis elegans

456

5

4

4

4

4.3

17555176

Cel26

Caenorhabditis elegans

523

4

4

4

5

4.3

17538332

Dme1

Drosophila melanogaster

721

8

5

4

3

5.0

21358115

Dme2

Drosophila melanogaster

809

4

4

2

5

3.8

33589428

Dme3

Drosophila melanogaster

535

5

6

5

5

5.3

24664569

Dme4

Drosophila melanogaster

460

5

5

4

5

4.8

24664565

Hsa1(B1)4

Homo sapiens

585

6

4

4

4

4.5

6175195

Hsa2(B2)4

Homo sapiens

509

6

5

4

6

5.3

38503353

Hsa3(B3)4

Homo sapiens

473

4

3

3

3

3.3

23397576

Hsa4(B4)4

Homo sapiens

668

6

7

5

6

6.0

38503351

Mfa

Macaca fascicularis

585

5

4

4

4

4.3

34013781

Mmu1

Mus musculus

551

6

4

2

2

3.5

28551155

Mmu2

Mus musculus

508

6

5

4

6

5.3

38503324

Mmu3

Mus musculus

453

5

7

5

6

5.8

38078711

Mmu4

Mus musculus

687

6

4

4

4

4.5

38090777

Rno1

Rattus norvegicus

513

5

4

4

5

4.5

34861871

Rno2

Rattus norvegicus

456

6

5

4

6

5.3

34851530

Rno3

Rattus norvegicus

454

4

7

5

6

5.5

34870281

Rno4

Rattus norvegicus

682

6

4

4

5

4.8

34865050

Str1

Silurana tropicalis

510

5

4

4

4

4.3

38174425

Xla1

Xenopus laevis

512

6

4

4

4

4.5

27881775

Xla2

Xenopus laevis

512

5

4

4

5

4.5

30526076

Fungal

 

 

 

 

 

 

 

 

Ani1

Aspergillus nidulans

499

4

4

4

4

4.0

40744780

Ani2

Aspergillus nidulans

390

3

3

2

2

2.5

40738402

Mgr1

Magnaporthe grisea

512

5

5

5

6

5.3

38108763

Ncr1

Neurospora crassa

543

5

5

4

6

5.0

32419767

 

1Incomplete sequences and splice variants of a single gene product were not included.

 

2# TMSs, number of putative transmembrane a-helical spanners. The averages of the values obtained with four different programs are reported (see Methods section). The values obtained with each of the four programs can be found in table S1 on our website.

 

3gi Number, GenBank index number

 

4B1=Bestrophin-1 (VMD2); B2=VMD2-like protein 1; B3=VMD2-like protein 2; B4=VMD2-like protein 3