RECENT PUBLICATIONS

From Pub Med

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Dejean, A. S., Deisner, D. R., Kerdiles, Y. M., Babour, A., Arden, K., Castrillon, D. H., DePinho, R. A., Hedrick, S. M. (2009) Foxo3 controls the magnitude of T cell immune responses by modulating dendritic cell function. Nat Immunol. 10(5):457-8. Full Article

Kerdiles, Y. M., Beisner, D. R., Tinoco, R., Dejean, A. S., Castrillon, D. H., DePinho, R. A., Hedrick, S. M. (2009) Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nature Immunology. 10(2): 176-84. Epub 2009 Jan 11. Full Article

D'Souza, W. N., Chang, C. F., Fischer, A. M., Li, M., and Hedrick, S. M. (2008). The Erk2 MAPK regulates CD8 T cell proliferation and survival. J Immunol 181, 7617-7629. Full Article

McGargill, M. A., Choy, C., Wen, B. G., and Hedrick, S. M. (2008). Drak2 regulates the survival of activated T cells and is required for organ-specific autoimmune disease. J Immunol 181, 7593-7605. Full Article

Ch'en, I. L., Beisner, D. R., Degterev, A., Lynch, C., Yuan, J., Hoffmann, A., and Hedrick, S. M. (2008). Antigen-mediated T cell expansion regulated by parallel pathways of death. Proc Natl Acad Sci U S A 105, 17463-17468. Full Article.

Wang, S., Welte, T., McGargill, M., Town, T., Thompson, J., Anderson, J. F., Flavell, R. A., Fikrig, E., Hedrick, S. M., and Wang, T. (2008). Drak2 contributes to West Nile virus entry into the brain and lethal encephalitis. J Immunol 181, 2084-2091. Full Article

Ch'en, I. L., Hedrick, S. M., and Hoffmann, A. (2008). NF-kappaB as a determinant of distinct cell death pathways. Methods Enzymol 446, 175-187. Full Article

Degterev, A., Hitomi, J., Germscheid, M., Ch'en, I. L., Korkina, O., Teng, X., Abbott, D., Cuny, G. D., Yuan, C., Wagner, G., Hedrick, S. M., Gerber, S. A., Lugovskoy, A., and Yuan, J. (2008). Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol 4, 313-321. Full Article

Hedrick, S. M. (2008). Thymus lineage commitment: a single switch. Immunity 28, 297-299. Perspective. Full Article

Allen, J. J., Li, M., Brinkworth, C. S., Paulson, J. L., Wang, D., Hubner, A., Chou, W. H., Davis, R. J., Burlingame, A. L., Messing, R. O., Katayama, C. D., Hedrick, S. M., and Shokat, K. M. (2007). A semisynthetic epitope for kinase substrates. Nat Methods 4, 511-516. Full Article.

Peter, M. E., Budd, R. C., Desbarats, J., Hedrick, S. M., Hueber, A. O., Newell, M. K., Owen, L. B., Pope, R. M., Tschopp, J., Wajant, H., Wallach, D., Wiltrout, R. H., Zornig, M., and Lynch, D. H. (2007). The CD95 Receptor: Apoptosis Revisited. Cell 129, 447-450. Full Article

Hedrick, S. M. (2006). The TCR of mice and men. J Immunol 176, 2681-2682. Review-Perspective. Full Article

D'Souza, W. N., and Hedrick, S. M. (2006). Cutting edge: latecomer CD8 T cells are imprinted with a unique differentiation program. J Immunol 177, 777-781. Full Article

Broussard, C., Fleischacker, C., Horai, R., Chetana, M., Venegas, A. M., Sharp, L. L., Hedrick, S. M., Fowlkes, B. J., and Schwartzberg, P. L. (2006). Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk. Immunity 25, 93-104. Full Article

Fischer, A. M., Katayama, C. D., Pages, G., Pouyssegur, J., and Hedrick, S. M. (2005). The role of erk1 and erk2 in multiple stages of T cell development. Immunity 23, 431-443. Full Article

Beisner D. R., Ch'en I. L., Kolla R.V., Hoffmann A., and Hedrick S. M. (2005). Cutting Edge: Innate Immunity Conferred by B Cells Is Regulated by Caspase-8 J. Immunol. 175: Sept 15. Full Article

Hedrick SM, Cohen DI, Nielsen EA, Davis MM. Pillars article[A.Weiss]: Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. [Nature, 1984, 308: 149-153] J Immunol. 2005 Sep 1;175(5):2771-5 Full Article

Goldrath A. W., and Hedrick, S. M. Central Tolerance Matters. (2005) Immunity 23:113-114 Full Article

McGargill, M.A., Sharp, L.L., Bui, J.D., Hedrick, S.M., Calbo, S. Active Ca2+/Calmodulin-Dependent Protein Kinase II[gamma]B Impairs Positive Selection of T Cells by Modulating TCR Signaling (2005). J. Immunol. 175:656-664 Full Article

Catlett, I., and Hedrick, S. M. Suppressor of Cytokine Signaling 1 is required for differentiation of CD4 T Cells (2005). Nat Immunology, 6:715-21 Full Article

Lin, M. Y., Zal, T., Ch’en, I. L., Gascoigne, N. R. J., and Hedrick, S. M. (2005). A Pivotal Role for the Multifunctional Calcium/Calmodulin-dependent Protein Kinase II in T Cells: from Activation to Unresponsiveness. J. Immunol. 174:5583-92 Full Article

Sato, K, Imai, Y., Higashi, N., Kumamoto, Y., Onami, T. M., Hedrick, S. M. and Irimura, T. (2005). Lack of antigen-specific tissue remodeling in mice deficient in the macrophage galactose-type calcium-type lectin 1/CD301a. Blood, 106:207-215 Full Article

Scott, E. C., ... [S. M. Hedrick] et al. 2004. The Morphology of Steve. Annals of Improbable Research, 10:24-29. Full Article

Hedrick, S. M. The acquired immune system: a view from beneath. (2004) Immunity, 21:607-615 Full Article

Soloff, R. S., Katayama, C., Lin, M. Y., Feramisco, J. and Hedrick, S. M. (2004) Targeted deletion of PKC lambda reveals a distribution of functions between the two atypical PKC isoforms. J. Immunol. 173:3250-3260. Full Article

McGargill, M., Wen, B. G., Walsh, C. M., and Hedrick, S. M. (2004). A deficiency in Drak2 results in a T cell hypersensitivity, and an unexpected resistance to autoimmunity. Immunity, 21:781-791. Full Article

Brinkman-Van der Linden, E. C. M., Angata, T., Reynolds, S. A., Powell, L. D., Hedrick, S. M., and Varki, A. (2003) Mouse CD33/Siglec-3: binding specificity, expression pattern and consequences of gene deletion in mice. Mol Cell Biol. 23:4199-206 Full Article

Beisner, D. R., Chu, I. H., Arechiga, A. F., Hedrick, S. M. and Walsh, C. M. (2003). The requirements for Fas-associated death domain signaling in mature T cell activation and survival. J Immunol. 171:247-56. Full Article

Mertsching, E, Wurster, A., Katayama, C., Esko, J., Ramsdell, F., Marth, J. D., and Hedrick, S.M. (2002). A Mouse Strain Defective for ab vs. gd T Cell Lineage Commitment. Intl Immunol. 14(9):1039-53. Full Article

Hedrick, S. M. T cell lineage commitment: bottoms-up. (2002) Immunity, 16:619-622. Full Article

Tsujii, M., Fujimori, M., Oshashi, Y., Higashi, N., Onami, T. M., Hedrick, S. M., Irimura, T. (2002). Molecular Cloning and Characterization of a Novel Mouse Macrophage C-Type Lectin, mMGL2, Which Has a Distinct Carbohydrate Specificity from mMGL1. J Biol Chem. 277(32):28892-901. Full Article

Onami, T.M., Page, D.M., Bui, J., Varki, A., Varki, N., and Hedrick, S.M. (2002) The generation of mice deficient for the macrophage galactose and N-acetylgalactosamine specific lectin: limited role in lymphoid and erythroid homeostasis, and evidence for multiple lectins. Mol. and Cell. Bio. 14:5173-81. Full Article

Bain G, Cravatt CB, Loomans C, Alberola-Ila J, Hedrick SM, Murre C. (2001) Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade. Nat Immunol. 2:165-71. Full Article

Hayden-Martinez, K., Kane, L.P., and Hedrick, S.M. (2000). Effects of a constitutively active form of calcineurin on Tcell activation and thymic selection. J. Immunol., 165:3713-3712. Full Article

Jespen K., Hermanson, O., Onami, T. M., Gleiberman, A. S., Lunyak V., McEvilly, R.J., Kurokawa, R., Kumar, V., Liu, F., Seto, E., Hedrick, S.M., Mandel, G., Glass, C.K., Rose, D.W., and Rosenfeld, M.G. (2000). Combinatorial Roles of the Nuclear Receptor Corepressor in Transcription and Development. Cell 102:753-763. Full Article

Bui, J., Calbo, S., Hayden-Martinez, K., Kane, L., Gardner, P., and Hedrick, S.M. (2000) A role for CAMKII in T cell memory. Cell 100:457-468. Full Article

Bain, G., Quong, M.W., Soloff, R.S., Hedrick, S.M. and Murre C. (1999) Thymocyte maturation is regulated by the activityy of the helix-loop-helix protein, E47. J Exp Med 190:1605-16. Full Article

Sharp, L.L., and Hedrick, S.M. (1999) Commitment to the CD4 lineage by Erk MAP kinase and Lck signaling. J. Immunol., 163:6598-6605.Full Article

Hedrick, S.M., and Sharp, L.L. (1998) T-cell fate. Immun. Rev., 165:95-110. NOT AVAILABLE IN PDF

Schwarz, D.A., Katayama, C.D., and Hedrick, S.M. (1998) Schlafen, a new family of growth regulators affect thymocyte development. Immunity, 9:657-668.Full Article

Jemmerson, R., Minnerath, J.M., Hedrick, S.M., and Oehen, S. (1998) B cell tolerance to a minor but not to a major antigenic surface of the self antigen cytochrome. J. Immunol., 161:2841-2847.Full Article

Walsh, C.M., Wen, B.G., Chinnaiyan, A. M., O'Rourke, K., Dixit, V. M., and Hedrick, S.M. (1998) A role for FADD in T cell activation and development. Immunity, 8:439-449.Full Article

Page, D.M., Roberts, E.M., Peschon, J.D., and Hedrick, S.M. (1998) TNF receptor-deficient mice reveal startling differences between several modes of thymocyte negative selection. J. Immunol., 160:120-133.Full Article

Sharp, L.L., Schwarz, D.A., Bott, C.M., Marshall, C.J., and Hedrick, S.M. (1997) The influence of the MAPK pathway on T cell lineage commitment. Immunity, 7:609-618.Full Article

Weintraub, B.C., Eckmann, L., Okamoto, S., Hense, M., Hedrick, S.M., and Fierer, J. (1997) Role of ab and gd T cells in the host response to Salmonella infection as demonstrated in T cell receptor deficient mice of defined ITY genotype. Infection & Immunity, 65:2306-2312.Full Article