Publications 2004 - Present

Chisholm, R.L. and R.A. Firtel (2004). Insights into morphogenesis from a simple developmental system. Nature Rev. Mol. Cell Biol. 5:531-541. Full text Abstract

Sasaki, A.T., C. Chun, K. Takeda and R.A. Firtel (2004). Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement.  J. Cell Biol. 167:505-518. Full text Abstract

Park, K.C., F. Rivero, R. Meili, S. Lee, F. Apone and R.A. Firtel (2004). Rac regulation of chemotaxis and morphogenesis inDictyostelium. EMBO J. 23:4177-4189. Full text Abstract

Lee, S., F. Rivero, K.C. Park, E. Huang, S. Funamoto and R.A. Firtel (2004).  Dictyostelium PAKc is required for proper chemotaxis.  Mol. Biol. Cell 15:5456-5469.  Full text Abstract

Funamoto, S. and R.A. Firtel (2004).  Directional sensing: Subcellular targeting of GPCR downstream effectors during chemotaxis.  In: Cell Motility: From Molecules to Organisms.  5th Abercrombie Symposium on Cell Behaviour,  Wiley-Liss Inc., Chapter 17.

Kimmel, A.R. and R.A. Firtel (2004).  Breaking symmetries: regulation of Dictyostelium development through chemoattractant and morphogen signal-response.  Curr. Opin. Genet. Devel. 14:540-549.  Full text Abstract

Meili, R., A.T. Sasaki and R.A. Firtel (2005).  Rho rocks PTEN.  Nature Cell Biol. 7:334-335.  Full text Abstract

Myers, S.A., J.W. Han, Y. Lee, R.A. Firtel and C.Y. Chung (2005).  A Dictyostelium homologue of WASP is required for polarized F-actin assembly during chemotaxis.  Mol. Biol. Cell 16:2191-2206.  Full text Abstract

Mendoza, M.C., F. Du, N. Iranfar, N. Tang, H. Ma, W.F. Loomis and R.A. Firtel (2005).  Loss of SMEK, a novel, conserved protein, suppresses mek1 null cell polarity, chemotaxis, and gene expression defects.  Mol. Cell. Biol. 25:7839-7853. Full text Abstract

Lee, S., F.I. Comer, A. Sasaki, I.X. McLeod, Y. Duong, K. Okamura, J.R. Yates III, C.A. Parent and R.A. Firtel (2005).  TOR Complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium.  Mol. Biol. Cell 16:4572-4583. Full text Abstract

Charest, P.G. and R.A. Firtel (2006).  Feedback signaling controls leading-edge formation during chemotaxis.  Curr. Opin. Genet. Devel. 16:339-347. Full text Abstract

Mendoza, M.C. and R.A. Firtel (2006).  Assaying chemotaixs of Dictyostelium cells.  In: Methods in Molecular Biology, Vol. 346:Dictyostelium discoideum Protocols, (eds. L. Eichinger and F. Rivero), New Jersey: Humana Press, pp. 393-405.  Full text, Abstract

Sasaki, A.T. and R.A. Firtel (2006).  Regulation of chemotaxis by the orchestrated activation of Ras, PI3K, and TOR.  Eur. J. Cell Biol. 85:873-895.  Full text Abstract

Charest, P. and R.A. Firtel (2007).  Big roles for small GTPases in the control of directed cell movement.  Biochem. J. 401:377-390.  Full text Abstract

Jeon, T.J., D. Lee, S. Merlot, N. Nguyen, G. Weeks and R.A. Firtel (2007).  Rap1 controls cell adhesion and cell motility through the regulation of myosin II.  J. Cell Biol. 176:1021-1033.  Full text Abstract

Mendoza, M.C., E.O. Booth, G. Shaulsky and R.A. Firtel (2007).  MEK1 and protein phosphatase 4 coordinate Dictyostelium development and chemotaxis.  Mol. Cell. Biol. 27:3817-3827.  Full text Abstract

Takeda, K., A.T. Sasaki , H. Ha, H. Seung and R.A. Firtel (2007).  Role of phosphatidylinositol 3-kinases in chemotaxis in Dictyostelium.  J. Biol. Chem. 282:11874-11884.  Full text Abstract

Sasaki, A., C. Janetopoulos, S. Lee, P.G. Charest, K. Takeda, L.W. Sundheimer, R. Meili, P.N. Devreotes and R.A. Firtel (2007).  G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility.  J. Cell Biol. 178:185-191.  Full text Abstract

Del Alamo, J.C., R. Meili, B. Alonso-Latorre, J. Rodriguez-Rodriguez, A. Aliseda, R.A. Firtel and J.C. Lasheras (2007).  Spatio-temporal analysis of eucaryotic cell motility by improved force cytometry.  Proc. Natl. Acad. Sci. USA 104:13343-13348.  Full text Abstract

Kolsch, V., P.G. Charest and R.A. Firtel (2008)  The regulation of cell motility and chemotaxis by phospholipid signaling.  J. Cell Sci. 121:551-559. (Invited Review)

Janetopoulos, C. and R.A. Firtel (2008).  Directional sensing during chemotaxis.  FEBS Lett. 582:2075-2085. (Invited Review Issue)

Araki, T., J. Langenick, M. Gamper, R.A. Firtel and J.G. Williams (2008).  Evidence that DIF-1 and hyper-osmitic stress activate a Dictyostelium STAT by inhibiting a specific protein tyrosine phosphatase. Development 135:1347-1353.

Jeon, T.J., D. Lee, S. Lee, G. Weeks and R.A. Firtel (2007).  Regulation of Rap1 activity by RapGAP1 controls cell adhesion at the front of chemotaxing cells.  J. Cell Biol. 179:833-843.

Du, F., K. Edwards, Z. Shen, B. Sun, A. De Lozanne, S. Briggs and R.A. Firtel (2008).  Regulation of contractile vacuole formation and activity in Dictyostelium.  EMBO J., in press.

Zhang, S, P.G. Charest and R.A. Firtel (2008). Spatio-temporal regulation of Ras activity provides directional sensing. Curr. Biol., in press.