Publications 1998-2003

Han, Z. and R.A. Firtel (1998). The homeobox-containing gene Wariai regulates anterior-posterior patterning and cell-type homeostasis in Dictyostelium. Development 125:313-325. Full text Abstract

Cubitt, A.B., I. Reddy, S. Lee, J.G. McNally and R.A. Firtel (1998). Coexpression of a constitutively active plasma membrane calcium pump with GFP identifies roles for intracellular calcium in controlling cell sorting during morphogenesis in Dictyostelium. Devel. Biol. 196:77-94. Abstract

Aubry, L. and R.A. Firtel (1998). Spalten, a protein containing G-alpha-protein-like and PP2C domains, is essential for cell-type differentiation in Dictyostelium. Genes Devel. 12:1525-1538. Full text Abstract

Yasukawa, H., S. Mohanty and R.A. Firtel (1998). Identification and analysis of a gene that is essential for morphogenesis and prespore cell differentiation in Dictyostelium. Development 125:2565-2576. Full text Abstract

Sukumaran, S., J.M. Brown, R.A. Firtel and J.G. McNally (1998). lagC-null and gbf-null cells define key steps in the morphogenesis of Dictyostelium mounds.

Devel. Biol. 200:16-26. Full text

Araki, T., M. Gamper, A. Early, M. Fukuzawa, T. Abe, E. Kim, R.A. Firtel and J.G. Williams (1998). Developmentally and spatially regulated activation of a Dictyostelium STAT protein by a serpentine receptor. EMBO J. 17:4018-4028. Full text Abstract

Brown, J.M. and R.A. Firtel (1998) Phosphorelay signaling: New tricks for an ancient pathway. Curr. Biol. 8: R662-R665.

Chung, C., T.B.K. Reddy, K. Zhou and R.A. Firtel (1998). A novel, putative MEK kinase controls developmental timing and spatial patterning in Dictyostelium and is regulated by ubiquitin-mediated protein degradation. Genes Devel.12:3564-3578. Full text Abstract

Gamper, M., E. Kim, P.K. Howard, H. Ma, T. Hunter and R. A. Firtel (1999). Regulation of Dictyostelium protein-tyrosine phosphatase-3 (PTP3) through osmotic shock and stress stimulation and identification of pp130 as a PTP3 substrate. J. Biol. Chem.274:12129-12138. Full text Abstract

Meili, R., C. Ellsworth, S. Lee, T.B.K. Reddy, H. Ma and R.A. Firtel (1999). Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium. EMBO J. 18:2092-2105. Full text Abstract

Mohanty, S., K.A. Jermyn, A. Early, T. Kawata, L. Aubry, A. Ceccarelli, P. Schaap, J.G. Williams and R.A. Firtel (1999). Evidence that the Dictyostelium

Dd-STATa protein is a repressor that regulates commitment to stalk cell differentiation and is also required for chemotaxis.

Development 126:3391-3405. Full text Abstract

Lee, S., C.A. Parent, R. Insall and R.A. Firtel (1999). A novel Ras interacting protein required for chemotaxis and cyclic adenosine monophosphate signal relay in Dictyostelium. Mol. Biol. Cell 10:2829-2845. Full text Abstract

Chung, C.Y. and R.A. Firtel (1999). PAKa, a putative PAK family member, is required for cytokinesis and the regulation of the cytoskeleton in Dictyostelium discoideum cells during chemotaxis. J. Cell Biol. 147:559-575. Full text Abstract

Aubry, L. and R.A. Firtel (1999). Integration of signaling networks that regulate Dictyostelium differentiation. Ann. Rev. Cell Devel. Biol. 15:469-517. Full text Abstract

Chung, C.Y. and R.A. Firtel (2000). Dictyostelium: A model experimental system for elucidating the pathways and mechanisms controlling chemotaxis. In: Principles of Molecular Regulation (eds. P.M. Conn and A. Means), Totowa, NJ: The Humana Press, pp. 99-114. Full text

Brown, J.M. and R.A. Firtel (2000). Regulation of cell-fate determination in Dictyostelium. Devel. Biol. 216:426-441. Full text Abstract

Mohanty, S. and R.A. Firtel (2000). Control of spatial patterning and cell-type proportioning in Dictyostelium. Sem. Cell Devel. Biol. 10:597-607. Full text Abstract

Chien, S., C. Chung, S. Sukumaran, N. Osborne, S. Lee, C. Ellsworth, J.G. McNally and R.A. Firtel (2000). The Dictyostelium LIM domain-containing protein LIM2 is essential for proper chemotaxis and morphogenesis. Mol. Biol. Cell 11:1275-1291. Full text Abstract

Chung, C., S. Lee, C. Briscoe, C. Ellsworth and R.A. Firtel (2000). Role of Rac in controlling the actin cytoskeleton and chemotaxis in motile cells. Proc. Natl. Acad. Sci. USA. 97:5225-5230. Full text Abstract

Brown, J.M. and R.A. Firtel (2000). Just the right size: Cell counting in Dictyostelium. Trends Genet. 16:191-193. Full text Abstract

Firtel, R.A. and C.Y. Chung (2000). The molecular genetics of chemotaxis: Sensing and responding to chemoattractant gradients. BioEssays 22:603-615. Full text Abstract

Firtel, R.A. and R. Meili (2000). Dictyostelium: A model for regulated cell movement during morphogenesis. Curr. Opin. Genet. Devel. 10:421-427. Full text Abstract

Firtel, R.A. and D. Ish-Horowicz (2000). Differentiation and gene regulation: A rich developmental stew. Curr. Opin. Genet. Devel. 10:469-470.

Nelson, M.K., A. Clark, T. Abe, A. Nomura, N. Yadava, C.J. Funair, K.A. Jermyn, S. Mohanty, R.A. Firtel and J.G. Williams (2000). An F-box/WD40 repeat-containing protein important for Dictyostelium cell-type proportioning, slug behavior and culmination. Devel. Biol. 224:42-59. Full text Abstract

Meili, R., C. Ellsworth and R.A. Firtel (2000). A novel Akt/PKB-related kinase is essential for morphogenesis in Dictyostelium. Curr. Biol. 10:708-717. Full text Abstract

Williams, J.G. and R.A. Firtel (2000). HAPPY days for the Dictyostelium genome project. Genome Res. 10:1658-1659.

Wang, J., L. Hou, D. Awrey, W.F. Loomis, R.A. Firtel and C. Siu (2000). The membrane glycoprotein gp150 is encoded by the lagC gene and mediates cell-cell adhesion by heterophilic binding during Dictyostelium development. Devel. Biol. 227:734-745. Abstract

Early, A., M. Gamper, J. Moniakis, E. Kim, T. Hunter, J.G. Williams and R.A. Firtel (2001). Protein tyrosine phosphatase PTP1 negatively regulates Dictyostelium STATa and is required for proper cell-type proportioning. Devel. Biol. 232:233-245. Full text Abstract

Moniakis, J., S. Funamoto, M. Fukuzawa, J. Meisenhelder, T. Araki, T. Abe, R. Meili, T. Hunter, J. Williams and R.A. Firtel (2001). An SH2-domain-containing kinase negatively regulates the phosphatidylinositol-3 kinase pathway. Genes Devel. 15:687-698. Full text Abstract

Briscoe, C., J. Moniakis, J.Y. Kim, J.M. Brown, D. Hereld, P.N. Devreotes and R.A. Firtel (2001). The phosphorylated C-terminus of cAR1 plays a role in cell-type-specific gene expression and STATa tyrosine phosphorylation. Devel. Biol. 223:225-236. Full text Abstract

Chung, C.Y., G. Potikyan and R.A. Firtel (2001). Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa. Mol. Cell 7:937-947. Full text Abstract

Brown, J.M. and R.A. Firtel (2001). Functional and regulatory analysis of the Dictyostelium G-box binding factor. Devel. Biol. 234:521-534. Full text Abstract

Funamoto, S., K. Milan, R. Meili and R.A. Firtel (2001). Role of phosphatidylinositol 3' kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in Dictyostelium. J. Cell Biol. 153:705-809. Full text Abstract

Mohanty, S., S. Lee, N. Yadava, M.J. Dealy, R.S. Johnson and R.A. Firtel (2001). Regulated protein degradation controls PKA function and cell-type differentiation in Dictyostelium. Genes Devel. 15:1435-1448. Full text Abstract

Chung, C.Y., S. Funamoto and R.A. Firtel (2001). Signaling pathways controlling cell polarity and chemotaxis. Trends Biochem. Sci. 26:557-566
Full text Abstract Supplementary information

Sobko, A., H. Ma, and R A. Firtel (2002). Regulated SUMOylation and ubiquitination of DdMEK1 is required for proper chemotaxis. Devel. Cell 2:745-756. Full text Abstract

Funamoto, S., R. Meili, S. Lee, L. Parry and R.A. Firtel (2002). Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. Cell 109:611-623. Full text Abstract

Han, Y-H., C.Y. Chung, S. Stephens, D. Wessels, M.A. Titus, D.R. Soll and R.A. Firtel (2002). Requirement of a vasodilator-stimulated phosphoprotein (VASP) family member for cell adhesion, the formation of filopodia, and chemotaxis in Dictyostelium. J. Biol. Chem. 277:49877-49887. Full text Abstract

Meili, R and R.A. Firtel (2002). Leading the way. Nature Cell Biol. 4:E171. Full text Abstract

Sun, B. and R.A. Firtel (2003). A regulator of G protein signaling-containing kinase is important for chemotaxis and multicellular development in Dictyostelium. Mol. Biol. Cell 14:1727-1743. Full text Abstract

Merlot, S., R. Meili, D. Pagliarini, T. Maehama, J.E. Dixon and R.A. Firtel (2003). A PTEN-related 5’-phosphatidylinositol phosphatase localized in the Golgi. J. Biol. Chem. 278:39866-39873. Full text Abstract

Aubry, L., S. Lee, K. Ravanel and R.A. Firtel (2003). The novel ankyrin-repeat containing kinase ARCK-1 acts as a suppressor of the Spalten signaling pathway during Dictyostelium development. Devel. Biol. 263:308-322. Full text Abstract

Ridley, A.J., M.A. Schwartz, K. Burridge, R.A. Firtel, M.H. Ginsberg, G. Borisy, J.T. Parsons and A.R. Horwitz (2003). Cell migration: Integrating signals from front to back. Science 302:1704-1709. Full text Abstract